Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect

Abstract

In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and invasiveness in vitroand caused a decrease in the expression of a set of proteins specifically involved in growth, invasion and angiogenesis. In addition, CBD treatment caused a dose-related down-regulation of ERK and Akt prosurvival signaling pathways in U87-MG and T98G cells and decreased hypoxia inducible factor HIF-1α expression in U87-MG cells. Taken together, these results provide new insights into the antitumor action of CBD, showing that this cannabinoid affects multiple tumoral features and molecular pathways. As CBD is a non-psychoactive phytocannabinoid that appears to be devoid of side effects, our results support its exploitation as an effective anti-cancer drug in the management of gliomas.

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Medical Marijuana for Multiple Sclerosis: A Natural Treatment Option

Multiple SclerosisMultiple Sclerosis is an autoimmune disease that affects the central nervous system. It occurs when the myelin sheath, the covering that protects nerve cells, begins to break down. The nerve cells then become inflamed and damaged, causing painful symptoms, and making life extremely difficult for the sufferer.

Multiple sclerosis symptoms range from mild to severe, and can affect the entire body. Vision problems, muscle weakness and spasms, balance and coordination difficulties, and cognitive problems are all symptoms of the illness. These can be painful and debilitating for the sufferer, although with treatment they can be managed. There is currently no cure for the disease.

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Treatment for multiple sclerosis addresses the symptoms and can include pain management techniques and painkillers. Unfortunately, the long term effects of these can be very dangerous to the patient. Pain management drugs, especially narcotics, can damage the kidneys with prolonged use. They are also toxic in high doses, and patients can become addicted to them.

An alternative treatment for pain and muscle spasms in Multiple Sclerosis is the use of medical Marijuana, or Cannabis. There are numerous forms of medicating besides smoking for benefits. There are also non-psychoactive alternatives, meaning they will not “get you high”. Patients have reported less muscle spasticity and pain when they used Marijuana. They report feeling looseness in muscles for several hours after using medicinal Marijuana as well.

Patients taking medical Marijuana benefit from a reduction of spasticity in their muscles, as well as a reduction in pain and stiffness. The use of medical Marijuana can improve the quality of life for Multiple Sclerosis without further damaging the body.

Patients are fortunate to have a natural, effective alternative to pharmaceuticals in the treatment of Multiple Sclerosis. With medical Marijuana, they can find the relief that they’ve been searching for, with quick, safe results.