The influence of cannabinoids on generic traits of neurodegeneration

Abstract:

Alzheimers-300x224In an increasingly ageing population, the incidence of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are rising. While the aetiologies of these disorders are different, a number of common mechanisms that underlie their neurodegenerative components have been elucidated; namely neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced trophic support. Current therapies focus on treatment of the symptoms and attempt to delay the progression of these diseases but there is currently no cure. Modulation of the endogenous cannabinoid system is emerging as a potentially viable option in the treatment of neurodegeneration. Endocannabinoid signalling has been found to be altered in many neurodegenerative disorders. To this end, pharmacological manipulation of the endogenous cannabinoid system, as well as application of phytocannabinoids and synthetic cannabinoids have been investigated. Signalling from the CB1 and CB2 receptors are known to be involved in the regulation of Ca2+ homeostasis, mitochondrial function, trophic support and inflammatory status, respectively, while other receptors gated by cannabinoids such as PPARγ, are gaining interest in their anti-inflammatory properties. Through multiple lines of evidence, this evolutionarily conserved neurosignalling system has shown neuroprotective capabilities and is therefore a potential target for neurodegenerative disorders. This review details the mechanisms of neurodegeneration and highlights the beneficial effects of cannabinoid treatment.

Clinical Trials, Studies and Publications:

This review details the mechanisms of neurodegeneration and highlights the beneficial effects of cannabinoid treatment.

Medical Marijuana Effective in Treating Parkinson’s Disease

elderly woman thinksAnyone searching for a natural treatment for Parkinson’s Disease should investigate medical cannabis, more commonly known as medical marijuana, as a safe and effective natural treatment to relieve the symptoms of Parkinson’s. As a neurological disease, Parkinson’s changes the way a healthy brain uses dopamine, resulting in such symptoms as tremors, involuntary jerking motions, a stiff gait as well as a frozen appearance on the face. Muscular aches and pains are also very common in Parkinson’s Disease patients, as is mental confusion, feelings of stress, slowed or slurred speech, depression, anxiety and constipation.

Many patients currently taking pharmaceutical drugs to increase the amount of dopamine in the brain, not only suffer the high cost of using these drugs but also are subject to experiencing numerous negative side effects. Taking more than one drug can also cause additional side effects or negative reactions that simply replace one Parkinson’s Disease symptom with another without ever really helping the patient feel like they are getting an upper hand in managing their disease.

Clinical Trials, Studies and Publications:

Taking medical marijuana has proven to be a very effective natural treatment for eliminating or at least lessening many of the symptoms caused by Parkinson’s Disease. Patients who take medical marijuana often report an immediate lessening of their anxiety and depression. They feel more relaxed, less nervous and less anxious, which in turn helps their mental outlook considerably. Many patients find that they can let go of their anti-depressant medication and use medical marijuana instead. Many patients who are prescribed medical marijuana also report a marked decrease in the pain and overall achiness they experience on an on-going basis. As a result, their gait improves and they report being able to sleep much better, which benefits their overall mood and health.

Scientific research has also shown that medical marijuana is effective for its anti-oxidant properties, helping to forestall brain cell death, which is tremendously helpful when it comes to treating Parkinson’s Disease. Patients who use medical marijuana often enjoy an increased appetite. Because they are hungry enough to eat wholesome meals, their overall health benefits and many of the symptoms caused by Parkinson’s Disease are noticeably lessened.